c1 Refereed Journal Article. Available online August 17, 2012, print version published 2013. 22/7/14 HD. Green in Sherpa: Author's Pre-print: author can archive pre-print (ie pre-refereeing) Author's Post-print: author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: subject to Restrictions below, author can archive publisher's version/PDF General Conditions: •On author's personal website, institutional website or funder's website, including PubMed Central •Non-commercial use only •Publisher copyright and source must be acknowledged •Author's version can be used •Publisher's pdf can be used on institutional website, company website or funding agency website for a fee, Requested (Peng) Accepeted v. & Permission, 6.8.14-MMM. Full text added to dark upload for ERA LL 19/3/18