Facade systems are an integral part of modern day construction, especially with reinforced concrete structures. These facade systems are typically designed to withstand the effects of normal service loads and severe weather conditions. However, these elements are rarely designed to withstand the effects of an external explosion, which is considered as a rising threat to structural safety with the recent escalation of terrorist activities. In addition, these facade systems will act as the first layer of defence against an external explosion limiting the damage to the main structure. The aim of this research is to study the effects of blast loading on reinforced concrete facade systems. More specifically, the behaviour of reinforced concrete facade panels with flexible support conditions will be investigated. The overall aim was pursued by evaluating and utilising experimental studies relevant to this research to undertake 3-D finite element modelling using LS-DYNA and 1-D analytical modelling using a theoretical development. The validated numerical and analytical models were then utilised in a comprehensive parametric study.