Diurnal Actigraphy and Stimulant Efficacy in Narcolepsy

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/document/288 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/document/288 http://eprints.org/relation/isCoversheetVersionOf https://vuir.vu.edu.au/id/document/288 archive 34 disk0/00/00/02/99 2006-01-18 2021-08-27 14:08:36 2008-08-19 19:41:07 article show Bruck Dorothy Bruck, Dorothy Kennedy Gerard Kennedy, Gerard Cooper Amee Cooper, Amee Apel Sabine Diurnal Actigraphy and Stimulant Efficacy in Narcolepsy pub 320000 FOR_2008_170100 Psychology ResPubID9395, narcolepsy, actigraphy, stimulants, motor activity, mood; diurnal The aim of this study was to determine whether wrist actigraphy could be used to assess the daytime effects of stimulant medication treatment in narcolepsy. Nine subjects with narcolepsy/cataplexy (medicated and unmedicated) were compared with matched control subjects. Data was collected over four days in the subjects' home. It was found that the actigraph variable of Immobility (mean duration of periods of no activity) could be used to successfully differentiate medicated and unmedicated phases, correctly classifying 89% of cases. Narcolepsy subjects differed from controls on Immobility both when medicated and unmedicated. During the unmedicated phase self-reported nap duration was longer and more naps (3.94 naps) were taken. However, the frequency of naps was still high when medicated (2.43 naps). During the unmedicated phase narcolepsy subjects reported more negative mood states (Profile of Mood States, POMS) than control subjects. However, with the exception of Vigor, scores on the individual mood factors were within the normal range. Total POMS scores were highly correlated with the actigraphic measure of Movement for both narcolepsy conditions as well as controls, with negative mood associated with less movement. It was concluded that the actigraphy variable of Immobility is sensitive enough to detect treatment effects. The relationship between mood and motor activity warrants further investigation in both clinical and non-clinical populations. 2005 published John Wiley and Sons 10.1002/hup.666 https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.666 46736 2 2367579 dark_document 46736 Bruck Dorothy 4.pdf application/pdf 1a920825085716df2d04380c293e6d6d MD5 63152 2020-04-20 03:23:45 299 3 3 application/pdf text Permission Form en staffonly

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other public Human Psychopharmacology: Clinical and Experimental 20 2 105-113 TRUE 0885-6222 Includes bibliographical references: pp.112-113 FALSE 17 2-s2.0-14944353708 2023-07-01 04:03:00