The high prevalence of Adverse Events (AEs) in Australian hospitals and their effects on patient outcomes is a major concern among healthcare service organizations and authorities. The contributing factors which exacerbate this situation, such as the effect of intensified hospital workload on AEs have not been adequately examined in the previous literature. The few studies that have concentrated on the association of hospital workload with AEs have methodological drawbacks due to insufficient numbers of Hospital Workload Indicators (HWIs) employed and the limitation of dimensions that include different types of HWIs. This thesis aims to examine the association of HWIs with AEs using indicators drawn from a hospital episode dataset.