Thesis by publication. Chapter 2B - version not specified - no permissions found that permit inclusion. Removed Chapter 3 - published version - not permitted. Removed Chapter 4. - published version - no permissions found that permit inclusion. Removed. Chapter 5. - published version - permitted by publisher. https://www.springer.com/gp/rights-permissions/obtaining-permissions/882 "Authors have the right to reuse their article’s Version of Record, in whole or in part, in their own thesis. Additionally, they may reproduce and make available their thesis, including Springer Nature content, as required by their awarding academic institution. Authors must properly cite the published article in their thesis according to current citation standards. Material from: 'AUTHOR, TITLE, JOURNAL TITLE, published [YEAR], [publisher - as it appears on our copyright page]’" Set statement included. Signature on PDF removed and full-text attachment replaced. LM 07/07/20