Signature on PDF removed and full-text attachment replaced. LM 02/07/20 Thesis by publication. Chapter 2 & 3 - Elsevier publications. Elsevier has a policy of allowing published articles to remain in theses. https://www.elsevier.com/about/policies/copyright/permissions (click on Can I include/use my article in my thesis/dissertation) Chapter 4 - No permissions found that permit chapter 4 to be included. https://onlinelibrary.wiley.com/terms-and-conditions "Users shall not have the right to incorporate any material from the Electronic Products into any institutional or other repository under any circumstances without Wiley’s prior written approval". Paper was removed, and a page inserted with title and link to full-text. Chapter 5 & 6 - to date have not been published; currently permitted. LM 02/07/20