Some chapters are adaptions of published works and as such this thesis has not been treated as a thesis by publication. Chapter 3 content is very similar to published version; which is permitted for inclusion as it was published by Elsevier. Elsevier has a policy of allowing published articles to remain in theses. https://www.elsevier.com/about/policies/copyright/permissions (click on Can I include/use my article in my thesis/dissertation) LM 23/01/20