Thesis was embargoed for 6 months, but embargoed expired on 04/02/2019 LM 10/06/20 "all chapters in manuscript form to highlight the publishable quality of my thesis. Chapters (3-7) in this thesis are either in review or being prepared as manuscripts for publication, with chapters 3, 6 and 7 in submission to the Journal of Metabolism (Clinical and Experimental), Journal of Clinical Endocrinology, and Metabolism and BMC Trials respectively.." (pg. 28) Chapter 3, 4, 5, 6, 7 - at the time of processing thesis for inclusion in the repository, was unable to locate a published version of these chapters - to date they have not been officially published. LM 22/06/2020 Query with C&ML LM 22/06/20 C&ML confirmed thesis could go live as is - contains no currently published works. LM 07/07/20