predictive preventive personalized medicine, 3PM/PPPM, phytochemicals, flavonoids, flavanones, flavonols, flavones, flavanols, isofavonoids, chalcones, anthocyanidins, anti-cancer agents, drug-sensitizing efect, targeted therapy, radiotherapy, chemotherapy, immunotherapy, therapy resistance, anti-infammation, antibacterial, anti-viral, COVID-19, signalling pathways, therapy efcacy, nano-carrier delivery, disease management, health economy, health policy