Background: Public health system is connected to a complex dynamic of overall systematic processes of socio-political structure. Therefore, ensuring a high-quality digital healthcare system has inter-connected impacts on the war of COVID-19 prevention and beneficial for the health and welfare of people. Adopting an electronic vaccination registration system in Bangladesh has already made a huge impact in bringing the huge population under the vaccine scheme in a responsive manner. However, the country still has been struggling to achieve a systematic and technical strength due to a range of issues such as technical knowledge of healthcare professionals in providing services (for instance, e-healthcare services), use of tech tools and their application, developing and managing data, data visualization, and data availability.

Objective: The advancement of the health information system (HIS) develops the entire healthcare service in a country. This paper aims to explore how a developing country like Bangladesh has been fighting the COVID-19 pandemic and how the adoption of a robust digital health information system can impact the overall health and living conditions of the large population at stake.

Method: Based on system thinking and modeling, this study provided and described information based on existing data obtained from different inter-connecting sources with contributions to the systematic approach indicating a brief statistical data analysis.

Results: This study finds out that adopting a rigorous digital health information system during COVID-19 helped Bangladesh immensely to fight the ongoing pandemic and minimized the overall risks, but she still has a lot of scope to improve.