In the context of Smart Cities, Smart Heritage has emerged as a forward-oriented strategy aimed at enhancing the construction, management, accessibility, and sustainability of culturally significant environments. Yet, within Smart Heritage discourse, the distinction between basic digital representations and truly responsive, sensor-informed systems remains underdeveloped. This study addresses this gap by proposing a machine learning–enhanced digital twin simulation framework that enables both real-time and anticipatory heritage interventions. Using Chinatown Melbourne as an urban heritage case study, five open-access urban datasets, pedestrian counting, on-street parking, microclimate conditions, dwelling functionality, and Microlab sensor data (CO₂, sound level, and accelerometer), were evaluated, with three integrated into a pilot simulation model. A key contribution is the inclusion of a conceptual ‘Heritage Layer’ that overlays cultural significance and symbolic meaning across all stages of system logic and design response. The model also incorporates a dedicated machine learning layer, trained on full-year 2024 sensor data, to forecast environmental and behavioural triggers such as crowd build-up. This predictive capability enables the system to shift from reactive monitoring to proactive design interventions aligned with cultural rhythms. A December 2024 simulation validated the frequency and relevance of trigger-based activations. Rather than relying on platform-specific code, the framework is designed for adaptability across construction informatics environments and heritage precincts globally. Findings demonstrate how Smart Heritage systems can bridge environmental sensing, cultural identity, and post-construction evaluation, offering a scalable methodology for digitally responsive, culturally attuned urban heritage management.