The anti-atherogenic effects of thiazolidinediones

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/document/557 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/document/557 http://eprints.org/relation/isCoversheetVersionOf https://vuir.vu.edu.au/id/document/557 archive 164 disk0/00/00/07/50 2008-02-26 2024-07-02 01:30:18 2008-08-19 23:08:03 article show Stojanovska Lily Stojanovska, Lily Honisett Suzy Komesaroff Paul A Komesaroff, Paul A The anti-atherogenic effects of thiazolidinediones pub 320000 BiomedicalSciences diabetes, thiazolidinediones, lipids, endothelium, menopause The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced fasting glucose, insulin and glycated haemoglobin and they delay the progression of insulin resistance/impaired glucose tolerance into T2DM. It is well recognized that adequate glycaemic control and subsequent amelioration of hyperinsulinaemia and hyperglycaemia can delay the onset of vascular complications. TZDs, however, also have a number of anti-atherogenic effects independent of their influences on glucose and insulin metabolism. They improve lipid profiles, lower blood pressure, have anti-inflammatory properties, improve endothelial function and increase large artery compliance in patients with type 2 diabetes mellitus. When compared to rosiglitazone, pioglitazone has more favourable effects on the lipid profiles of patients with T2DM. The disease preventive actions of TZDs may be the result of their agonistic effects on peroxisome proliferator-activated receptors (PPARs), ligand-activated transcription factors that regulate the expression of numerous genes and affect metabolism and vascular parameters. Thiazolidinediones, provide an effective treatment for populations with insulin resistance which is at high risk of developing cardiovascular disease. This paper discusses the differences between ROS and PIO and explores their anti-atherogenic effects with particular focus on post-menopausal women with type 2 diabetes mellitus. 2007 published 48121 4 2370915 dark_document 48121 CorrespondenceSL.pdf application/pdf 9dc974abca1479a0a997b9b088010a36 MD5 113878 2020-05-18 01:58:33 750 3 3 application/pdf text Correspondence - (Pub Permission on p.3) en staffonly

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other public Current Diabetes Review 3 1 67-74 UNSPECIFIED FALSE 1573-3998 includes references: pp. 72-74 FALSE 9 2-s2.0-34247096912 2023-07-01 04:03:56