Depression is more prevalent in obese individuals and those with diabetes, compared to the general population. Depression may also be a major risk factor for obesity and its related complications (such as type 2 diabetes (T2DM)) as it may lead to behavioural changes (i.e. reduced physical activity and increased energy intake). This randomised study examined the effect of resistance training (RT) on depressed mood of individuals with high (HiMF, n > 2) and low (LoMF, n < 1) numbers of metabolic riskfactors forT2DM as well as the validity and reliability of the cardiac depression scale (CDS) for these populations.