The article proposes an intelligent framework for supporting Web-based applications. The framework focuses on innovative use of existing resources and technologies in the form of services and takes the leverage of theoretical foundation of services science and the research from services computing. The main focus of the framework is to deliver benefits to users with various roles such as service requesters, service providers, and business owners to maximize their productivity when engaging with each other via the Web. The article opens up with research motivations and questions, analyses the existing state of research in the field, and describes the approach in implementing the proposed framework. Finally, an e-health application is discussed to evaluate the effectiveness of the framework where participants such as general practitioners (GPs), patients, and health-care workers collaborate via the Web.