The prevalence of obesity and its associated conditions, such as hypertension, dyslipidemia, and insulin resistance, has proliferated worldwide over the past 2 decades. Depression is more prevalent in obese individuals and patients with diabetes, compared to in the general population. Resistance exercise training (RT) is a simple and effective method to improve depressed mood in this population and should form an important part of the exercise training regimens for people at a high risk of developing Type 2 diabetes and cardio-vascular disease.