Article

Voisin, Sarah ORCID: 0000-0002-4074-7083, Seale, Kristen, Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie ORCID: 0000-0002-7658-030X, Harvey, Nicholas ORCID: 0000-0003-2035-8475, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Griffiths, Lyn R ORCID: 0000-0002-6774-5475, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Coffey, Vernon G, Thompson, Jamie-Lee M, Doering, Thomas M, Lindholm, Malene E, Walsh, Colum, Davison, Gareth, Irwin, Rachelle, McBride, Catherine, Hansson, Ola, Asplund, Olof, Heikkinen, Aino E, Piirilä, Päivi, Pietiläinen, Krisi H., Ollikainen, Miina, Blocquiaux, Sara, Thomis, Martine, Coletta, Dawn K, Sharples, Adam P and Eynon, Nir ORCID: 0000-0003-4046-8276 (2024) Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Aging Cell, 23 (1). ISSN 1474-9718

Hiam, Danielle ORCID: 0000-0003-0135-329X, Landen, Shanie ORCID: 0000-0002-7658-030X, Jacques, Macsue ORCID: 0000-0002-4337-7022, Voisin, Sarah ORCID: 0000-0002-4074-7083, Lamon, Severine ORCID: 0000-0002-3271-6551 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2023) Muscle miRNAs are influenced by sex at baseline and in response to exercise. BMC Biology, 21. ISSN 1741-7007

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie ORCID: 0000-0002-7658-030X, Romero, Javier Alvarez, Hiam, Danielle ORCID: 0000-0003-0135-329X, Schittenhelm, Ralf B ORCID: 0000-0001-8738-1878, Hanchapola, Iresha, Shah, Anup D ORCID: 0000-0002-3793-1998, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2023) Methylome and proteome integration in human skeletal muscle uncover group and individual responses to high-intensity interval training. The FASEB Journal, 37 (10). ISSN 0892-6638

Landen, Shanie ORCID: 0000-0002-7658-030X, Jacques, Macsue ORCID: 0000-0002-4337-7022, Hiam, Danielle ORCID: 0000-0003-0135-329X, Alvarez-Romero, Javier, Schittenhelm, Ralf B, Shah, Anup D, Huang, Cheng, Steele, Joel R, Harvey, Nicholas, Haupt, Larisa M, Griffiths, Lyn R, Ashton, Kevin J, Lamon, Severine ORCID: 0000-0002-3271-6551, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2023) Sex differences in muscle protein expression and DNA methylation in response to exercise training. Biology of Sex Differences, 14. ISSN 2042-6410

Feehan, Jack ORCID: 0000-0002-9627-1299, Jacques, Macsue ORCID: 0000-0002-4337-7022, Kondrikov, Dmitry, Eynon, Nir ORCID: 0000-0003-4046-8276, Wijeratne, Tissa, Apostolopoulos, Vasso ORCID: 0000-0001-6788-2771, Gimble, Jeffrey M, Hill, William D and Duque, Gustavo ORCID: 0000-0001-8126-0637 (2023) Circulating Osteoprogenitor Cells Have a Mixed Immune and Mesenchymal Progenitor Function in Humans. Stem Cells, 41 (11). pp. 1060-1075. ISSN 1066-5099

Moreland, Ethan, Cheung, Ada ORCID: 0000-0002-7158-8804, Hiam, Danielle ORCID: 0000-0003-0135-329X, Nolan, Brendan J ORCID: 0000-0001-8836-165X, Landen, Shanie ORCID: 0000-0002-7658-030X, Jacques, Macsue ORCID: 0000-0002-4337-7022, Eynon, Nir ORCID: 0000-0003-4046-8276 and Jones, Patrice ORCID: 0000-0002-4948-1445 (2023) Implications of gender-affirming endocrine care for sports participation. Therapeutic Advances in Endocrinology and Metabolism, 14. ISSN 2042-0188 (In Press)

Landen, Shanie ORCID: 0000-0002-7658-030X, Hiam, Danielle ORCID: 0000-0003-0135-329X, Voisin, Sarah ORCID: 0000-0002-4074-7083, Jacques, Macsue ORCID: 0000-0002-4337-7022, Lamon, S ORCID: 0000-0002-3271-6551 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2023) Physiological and molecular sex differences in human skeletal muscle in response to exercise training. Journal of Physiology, 601 (3). pp. 419-434. ISSN 0022-3751

Jones, Patrice ORCID: 0000-0002-4948-1445, Voisin, Sarah ORCID: 0000-0002-4074-7083, Nolan, Brendan J ORCID: 0000-0001-8836-165X, Landen, Shanie, Jacques, Macsue ORCID: 0000-0002-4337-7022, Newell, Beau, Zwickl, Sav, Cook, Teddy, Wong, Alex ORCID: 0000-0002-3666-5261, Ginger, Ariel, Palmer, Andrew, Garnham, Andrew, Alvarez-Romero, Javier, Mohandas, Namitha, Seale, Kirsten, Cheung, Ada and Eynon, Nir ORCID: 0000-0003-4046-8276 (2022) Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics: protocol for a prospective matched cohort study in transgender individuals (the GAME study). BMJ open, 12 (5). ISSN 2044-6055

Woessner, Mary ORCID: 0000-0001-7001-8407, Hiam, Danielle ORCID: 0000-0003-0135-329X, Smith, Cassandra ORCID: 0000-0002-2517-2824, Lin, X, Zarekookandeh, N, Tacey, Alexander ORCID: 0000-0002-0718-9665, Parker, L, Landen, Shanie ORCID: 0000-0002-7658-030X, Jacques, Macsue, Lewis, Joshua R, Brennan-Speranza, Tara ORCID: 0000-0001-5472-4969, Voisin, Sarah ORCID: 0000-0002-4074-7083, Duque, G, Eynon, Nir ORCID: 0000-0003-4046-8276 and Levinger, Itamar ORCID: 0000-0001-9194-2033 (2022) Osteoglycin across the adult lifespan. Journal of Clinical Endocrinology and Metabolism, 107 (4). ISSN 0021-972X

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie, Alvarez-Romero, Javier, Yan, Xu ORCID: 0000-0001-8547-4210, Hiam, Danielle ORCID: 0000-0003-0135-329X, Jones, Patrice ORCID: 0000-0002-4948-1445, Gurd, Brendon J, Eynon, Nir ORCID: 0000-0003-4046-8276 and Voisin, Sarah ORCID: 0000-0002-4074-7083 (2022) Implementation of multiple statistical methods to estimate variability and individual response to training. European Journal of Sport Science. ISSN 1746-1391

Alvarez-Romero, Javier, Laguette, Mary-Jessica N ORCID: 0000-0001-9979-117X, Seale, Kirsten, Jacques, Macsue ORCID: 0000-0002-4337-7022, Voisin, Sarah ORCID: 0000-0002-4074-7083, Hiam, Danielle ORCID: 0000-0003-0135-329X, Feller, Julian A, Tirosh, Oren, Miyamoto-Mikami, Eri, Kumagai, Hiroshi, Kikuchi, Naoki, Kamiya, Nobuhiro, Fuku, Noriyuki, Collins, Malcolm, September, Alison V ORCID: 0000-0003-0950-286X and Eynon, Nir ORCID: 0000-0003-4046-8276 (2021) Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan. European Journal of Sport Science. ISSN 1746-1391

Genders, Amanda ORCID: 0000-0001-7535-4071, Kuang, Jujiao ORCID: 0000-0002-1366-0089, Marin, EC, Saner, Nicholas ORCID: 0000-0002-6011-7126, Botella, Javier ORCID: 0000-0001-9722-8519, Jacques, Macsue ORCID: 0000-0002-4337-7022, McConell, Glenn ORCID: 0000-0002-8572-9065, Andrade-Souza, VA, Chagolla, J and Bishop, David ORCID: 0000-0002-6956-9188 (2021) Exercise does not improve insulin resistance and mitochondrial characteristics together. Journal of Endocrinology, 252 (2). pp. 91-105. ISSN 0022-0795

Landen, Shanie, Jacques, Macsue, Hiam, Danielle ORCID: 0000-0003-0135-329X, Alvarez-Romero, Javier, Harvey, Nicholas ORCID: 0000-0003-2035-8475, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Griffiths, Lyn R ORCID: 0000-0002-6774-5475, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Lamon, Severine ORCID: 0000-0002-3271-6551, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2021) Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism. Clinical Epigenetics, 13. ISSN 1868-7075

Voisin, Sarah ORCID: 0000-0002-4074-7083, Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie, Harvey, Nicholas ORCID: 0000-0003-2035-8475, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Griffiths, Lyn R ORCID: 0000-0002-6774-5475, Gancheva, Sofiya, Ouni, Meriem, Jähnert, Markus, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Coffey, Vernon G, Thompson, Jamie-Lee M, Doering, Thomas M, Gabory, Anne, Junien, Claudine, Caiazzo, Robert, Verkindt, Hélène, Raverdy, Violetta, Pattou, François, Froguel, Philippe, Craig, Jeffrey M, Blocquiaux, Sara, Thomis, Martine, Sharples, Adam P, Schürmann, Annette, Roden, Michael, Horvath, Steve ORCID: 0000-0002-4110-3589 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2021) Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, 12 (4). pp. 1064-1078. ISSN 2190-5991 (print) 2190-6009 (online)

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie, Alvarez-Romero, Javier, Yan, Xu ORCID: 0000-0001-8547-4210, Garnham, Andrew, Hiam, Danielle ORCID: 0000-0003-0135-329X, Siegwald, Mélina, Mercier, Emma, Hecksteden, Anne, Eynon, Nir ORCID: 0000-0003-4046-8276 and Voisin, Sarah ORCID: 0000-0002-4074-7083 (2021) Individual physiological and mitochondrial responses during 12 weeks of intensified exercise. Physiological Reports, 9 (15). ISSN 2051-817X

Williams, Camilla J, Li, Zhixiu, Harvey, Nicholas, Lea, Rodney A, Gurd, Brendon J, Bonafiglia, Jacob T, Papadimitriou, Ioannis D, Jacques, Macsue ORCID: 0000-0002-4337-7022, Croci, Ilaria, Stensvold, Dorthe, Wisloff, Ulrik, Taylor, Jenna L, Gajanand, Trishan, Cox, Emily R, Ramos, Joyce S, Fassett, Robert G, Little, Jonathan P, Francois, Monique E, Hearon, Christopher M, Sarma, Satyam, Janssen, SLJE, Van Craenenbroeck, Emeline M, Beckers, Paul, Cornelissen, Veronique A, Howden, Erin J, Keating, Shelley E ORCID: 0000-0001-5357-2721, Yan, Xu ORCID: 0000-0001-8547-4210, Bishop, David ORCID: 0000-0002-6956-9188, Bye, Anja, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Griffiths, Lyn R ORCID: 0000-0002-6774-5475, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Brown, Matthew, Torquati, Luciana, Eynon, Nir ORCID: 0000-0003-4046-8276 and Coombes, Jeff S (2021) Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study. Journal of Biomedical Science, 28. ISSN 1021-7770

Hiam, Danielle ORCID: 0000-0003-0135-329X, Landen, Shanie, Jacques, Macsue ORCID: 0000-0002-4337-7022, Voisin, Sarah ORCID: 0000-0002-4074-7083, Alvarez-Romero, Javier, Byrnes, Elizabeth, Chubb, Paul, Levinger, Itamar ORCID: 0000-0001-9194-2033 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2021) Osteocalcin and its forms respond similarly to exercise in males and females. Bone, 144. ISSN 8756-3282

Harvey, Nicholas ORCID: 0000-0003-2035-8475, Voisin, Sarah ORCID: 0000-0002-4074-7083, Lea, R, Yan, Xu ORCID: 0000-0001-8547-4210, Benton, Miles C ORCID: 0000-0003-3442-965X, Papadimitriou, Ioannis D, Jacques, Macsue ORCID: 0000-0002-4337-7022, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Eynon, Nir ORCID: 0000-0003-4046-8276 and Griffiths, Lyn R ORCID: 0000-0002-6774-5475 (2020) Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes. Scientific Reports, 10 (1). ISSN 2045-2322

Jacques, Macsue ORCID: 0000-0002-4337-7022, Kuang, Jujiao ORCID: 0000-0002-1366-0089, Bishop, David ORCID: 0000-0002-6956-9188, Yan, Xu ORCID: 0000-0001-8547-4210, Alvarez-Romero, Javier, Munson, Fiona, Garnham, Andrew, Papadimitriou, Ioannis D, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2020) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. The FASEB Journal, 34 (2). pp. 2978-2986. ISSN 0892-6638

Hiam, Danielle ORCID: 0000-0003-0135-329X, Smith, Cassandra, Voisin, Sarah ORCID: 0000-0002-4074-7083, Denham, J, Yan, Xu ORCID: 0000-0001-8547-4210, Landen, Shanie, Jacques, Macsue ORCID: 0000-0002-4337-7022, Alvarez-Romero, Javier, Garnham, Andrew, Woessner, Mary ORCID: 0000-0001-7001-8407, Herrmann, Markus, Duque, G, Levinger, Itamar ORCID: 0000-0001-9194-2033 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2020) Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan. Aging, 12 (1). pp. 359-369. ISSN 1945-4589

Harvey, Nicholas ORCID: 0000-0003-2035-8475, Voisin, Sarah ORCID: 0000-0002-4074-7083, Dunn, PJ, Sutherland, Heidi ORCID: 0000-0002-8512-1498, Yan, Xu ORCID: 0000-0001-8547-4210, Jacques, Macsue ORCID: 0000-0002-4337-7022, Papadimitriou, Ioannis D, Haseler, LJ, Ashton, Kevin J ORCID: 0000-0001-6106-3425, Haupt, Larisa M ORCID: 0000-0002-7735-8110, Eynon, Nir ORCID: 0000-0003-4046-8276 and Griffiths, Lyn R ORCID: 0000-0002-6774-5475 (2020) Genetic variants associated with exercise performance in both moderately trained and highly trained individuals. Molecular Genetics and Genomics, 295. pp. 515-523. ISSN 1617-4615

Papadimitriou, Ioannis D, Eynon, Nir ORCID: 0000-0003-4046-8276, Yan, Xu ORCID: 0000-0001-8547-4210, Munson, Fiona, Jacques, Macsue ORCID: 0000-0002-4337-7022, Kuang, Jujiao ORCID: 0000-0002-1366-0089, Voisin, Sarah ORCID: 0000-0002-4074-7083, North, KN and Bishop, David ORCID: 0000-0002-6956-9188 (2019) A “human knockout” model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Scientific Reports, 9. ISSN 2045-2322

Hiam, Danielle ORCID: 0000-0003-0135-329X, Voisin, Sarah ORCID: 0000-0002-4074-7083, Yan, Xu ORCID: 0000-0001-8547-4210, Landen, Shanie, Jacques, Macsue, Papadimitriou, Ioannis D, Munson, Fiona, Byrnes, Elizabeth, Brennan-Speranza, Tara, Levinger, Itamar ORCID: 0000-0001-9194-2033 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2019) The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: the gene SMART study. Bone, 123. pp. 23-27. ISSN 8756-3282

Jacques, Macsue ORCID: 0000-0002-4337-7022, Hiam, Danielle ORCID: 0000-0003-0135-329X, Craig, Jeffrey M ORCID: 0000-0003-3979-7849, Barresi, Romain, Eynon, Nir ORCID: 0000-0003-4046-8276 and Voisin, Sarah ORCID: 0000-0002-4074-7083 (2019) Epigenetic changes in healthy human skeletal muscle following exercise: a systematic review. Epigenetics. ISSN 1559-2294

Voisin, Sarah ORCID: 0000-0002-4074-7083, Jacques, Macsue, Lucia, A, Bishop, David ORCID: 0000-0002-6956-9188 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2019) Statistical Considerations for Exercise Protocols Aimed at Measuring Trainability. Exercise and Sport Sciences Reviews, 47 (1). pp. 37-45. ISSN 0091-6331

Yan, Xu ORCID: 0000-0001-8547-4210, Dvir, Noam, Jacques, Macsue, Cavalcante, Luiz, Papadimitriou, Ioannis D, Munson, Fiona, Kuang, Jujiao ORCID: 0000-0002-1366-0089, Garnham, Andrew, Landen, Shanie, Li, Jia, O'Keefe, Lannie ORCID: 0000-0002-0264-0007, Tirosh, Oren, Bishop, David ORCID: 0000-0002-6956-9188, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2018) ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the Gene SMART study. Journal of Applied Physiology, 125 (3). 923 - 930. ISSN 8750-7587

Papadimitriou, Ioannis D, Lockey, Sarah J, Voisin, Sarah ORCID: 0000-0002-4074-7083, Herbert, Adam J, Garton, Fleur, Houweling, Peter J, Cieszczyk, Pawel, Maciejewska-Skrendo, Agnieszka, Sawczuk, Marek, Massidda, Myosotis, Calò, Carla Maria, Astratenkova, Irina V, Kouvatsi, Anastasia, Druzhevskaya, Anastasiya M, Jacques, Macsue, Ahmetov, Ildus I, Stebbings, Georgina K, Heffernan, Shane, Day, Stephen H, Erskine, Robert M, Pedlar, Charles, Kipps, Courtney, North, Kathryn N, Williams, Alun G and Eynon, Nir ORCID: 0000-0003-4046-8276 (2018) No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. BMC Genomics, 19. ISSN 1471-2164

Possamai, Leonardo Trevisol, Zogo, Airton, Boni, Jhonatan, Jacques, Macsue ORCID: 0000-0002-4337-7022, Dorst, Lissandro Moisés and Dorst, Débora Bourscheid (2015) Fitness for elders: a comparison between practioners and non-practioners of exercise. Age, 37 (3). pp. 1-8. ISSN 0161-9152

Book Section

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie ORCID: 0000-0002-7658-030X, Palmer, Andrew and Eynon, Nir ORCID: 0000-0003-4046-8276 (2021) Epigenetic Effects of Exercise on Human Skeletal Muscle. In: Stress: Genetics, Epigenetics and Genomics. Fink, G, ed. Handbook of Stress, 4 . Academic Press, pp. 269-273.

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie, Voisin, Sarah ORCID: 0000-0002-4074-7083 and Eynon, Nir ORCID: 0000-0003-4046-8276 (2019) Summary Findings on Genetics and Sport Performance. In: Routledge Handbook of Sport and Exercise Systems Genetics. Lightfoot, JT, Hubal, MJ and Roth, SM, eds. Routledge International Handbooks . Routledge, London, pp. 347-356.

Jacques, Macsue ORCID: 0000-0002-4337-7022, Landen, Shanie, Voisin, Sarah ORCID: 0000-0002-4074-7083, Lamon, Séverine and Eynon, Nir ORCID: 0000-0003-4046-8276 (2018) Nurture vs. nature: the genetics and epigenetics of exercise. In: Research Methods in Physical Activity and Health. Bird, SR, ed. Routledge, London, pp. 21-27.

Jacques, Macsue ORCID: 0000-0002-4337-7022, Eynon, Nir ORCID: 0000-0003-4046-8276 and Hanson, Erik (2018) Genetics and Sprint, Strength, and Power Performance: Candidate Gene Versus Genome-Wide Association Study Approaches. In: Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Bagchi, Debasis, Nair, Sreejayan and Sen, Chandan K, eds. (2nd ed.) Elsevier, pp. 371-383.

Thesis

Jacques, Macsue (2020) The epigenetic basis of variable response to exercise training. PhD thesis, Victoria University.