Article

Cheng, Lesley ORCID: 0000-0002-8075-6144, Quek, Camelia ORCID: 0000-0002-1244-961X, Li, Xia, Bellingham, Shayne A ORCID: 0000-0001-5657-7413, Ellett, Laura, Shambrook, Mitch, Zafar, Saima, Zerr, Inga, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2021) Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease. Communications Biology, 4 (1). ISSN 2399-3642

Ugalde, Cathryn L ORCID: 0000-0001-8663-6437, Gordon, Shane E ORCID: 0000-0003-3964-8317, Shambrook, Mitch, Nasiri Kenari, Amirmohammad, Coleman, Bradley M, Perugini, Matthew A ORCID: 0000-0001-8052-5584, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Finkelstein, David I ORCID: 0000-0002-8167-4917 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2020) An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization. Journal of Extracellular Vesicles, 10 (2). ISSN 2001-3078

Ugalde, Cathryn L ORCID: 0000-0001-8663-6437, Lewis, Victoria A, Stehmann, Christiane, McLean, Catirona ORCID: 0000-0002-9259-8411, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Collins, Steven J and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2020) Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain. Brain Communications, 2 (2). ISSN 2632-1297

Ugalde, Cathryn L ORCID: 0000-0001-8663-6437, Annesley, Sarah J, Gordon, Shane E ORCID: 0000-0003-3964-8317, Mroczek, Katelyn, Perugini, Matthew A ORCID: 0000-0001-8052-5584, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Fisher, Paul R, Finkelstein, David I ORCID: 0000-0002-8167-4917 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2020) Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells. Disease Models and Mechanisms, 13 (1). ISSN 1754-8403

Ugalde, Cathryn L ORCID: 0000-0001-8663-6437, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Finkelstein, David I ORCID: 0000-0002-8167-4917 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2019) The role of lipids in -synuclein misfolding and neurotoxicity. Journal of Biological Chemistry, 294 (23). pp. 9016-9028. ISSN 0021-9258

Ugalde, Cathryn L, Finkelstein, David I, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2016) Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers. Journal of Neurochemistry, 139 (2). pp. 162-180. ISSN 0022-3042

Ellett, Laura, Coleman, Bradley M, Shambrook, Mitch, Johanssen, Vanessa A, Collins, Steven J, Masters, Colin L ORCID: 0000-0003-3072-7940, Hill, Andrew F ORCID: 0000-0001-5581-2354 and Lawson, Victoria A ORCID: 0000-0002-7362-7176 (2015) Glycosaminoglycan sulfation determines the biochemical properties of prion protein aggregates. Glycobiology, 25 (7). pp. 745-755. ISSN 0959-6658

Coleman, Bradley M, Harrison, Christopher F, Guo, Belinda B, Masters, Colin L ORCID: 0000-0003-3072-7940, Barnham, Kevin J ORCID: 0000-0003-1164-9465, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2014) Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality. Journal of Virology, 88 (5). pp. 2690-2703. ISSN 0022-538X

Cui, Huanhuan L, Guo, Belinda B, Scicluna, Benjamin J, Coleman, Bradley M, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Ellett, Laura, Meikle, Peter ORCID: 0000-0002-2593-4665, Bukrinsky, Michael ORCID: 0000-0002-8593-0770, Mukhamedova, Nigora, Sviridov, Dmitri ORCID: 0000-0002-8366-3832 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2014) Prion infection impairs cholesterol metabolism in neuronal cells. Journal of Biological Chemistry, 289 (2). pp. 789-802. ISSN 0021-9258

Coleman, Bradley M, Hanssen, Eric, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2012) Prion-infected cells regulate the release of exosomes with distinct ultrastructural features. FASEB Journal, 26 (10). pp. 4160-4173. ISSN 0892-6638

Klemm, Helen MJ, Welton, Jeremy M, Masters, Colin L ORCID: 0000-0003-3072-7940, Klug, Genevieve M, Boyd, Alison, Hill, Andrew F ORCID: 0000-0001-5581-2354, Collins, Steven J and Lawson, Victoria A ORCID: 0000-0002-7362-7176 (2012) The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes. Journal of Biological Chemistry, 287 (43). pp. 36465-36472. ISSN 0021-9258

Lewis, Victoria A, Haigh, Cathryn L, Masters, Colin L ORCID: 0000-0003-3072-7940, Hill, Andrew F ORCID: 0000-0001-5581-2354, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Collins, Steven J (2012) Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP res level disparity. Molecular Neurodegeneration, 7. ISSN 1750-1326

Lawson, Victoria A ORCID: 0000-0002-7362-7176, Furness, John B ORCID: 0000-0002-0219-3438, Klemm, Helen MJ, Pontell, Louise, Chan, Ewan, Hill, Andrew F ORCID: 0000-0001-5581-2354 and Chiocchetti, Roberto ORCID: 0000-0003-4448-6199 (2010) The brain to gut pathway: a possible route of prion transmission. Gut, 59. pp. 1643-1651. ISSN 0017-5749

Lawson, Victoria A ORCID: 0000-0002-7362-7176, Lumicisi, Brooke, Welton, Jeremy M, Machalek, Dorothy, Gouramanis, Katrina, Klemm, Helen M, Stewart, James D, Masters, Colin L ORCID: 0000-0003-3072-7940, Hoke, David E, Collins, Steven J and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2010) Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein. PLoS ONE, 5 (8). ISSN 1932-6203

Nisbet, Rebecca M, Harrison, Christopher F, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Masters, Colin L ORCID: 0000-0003-3072-7940, Cappai, Roberto ORCID: 0000-0002-9505-8496 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2010) Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease. Journal of Virology, 84 (13). pp. 6678-6686. ISSN 0022-538X

Harrison, Christopher F, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Coleman, Bradley M, Kim, Y-S, Masters, Colin L ORCID: 0000-0003-3072-7940, Cappai, Roberto ORCID: 0000-0002-9505-8496, Barnham, Kevin J ORCID: 0000-0003-1164-9465 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2010) Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity. Journal of Biological Chemistry, 285 (26). pp. 20213-20223. ISSN 0021-9258

Lewis, Victoria A, Hill, Andrew F ORCID: 0000-0001-5581-2354, Haigh, Cathryn L, Klug, Genevieve M, Masters, Colin L ORCID: 0000-0003-3072-7940, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Collins, Steven J (2009) Increased proportions of c1 truncated prion protein protect against cellular m1000 prion infection. Journal of Neuropathology and Experimental Neurology, 68 (10). pp. 1125-1135. ISSN 0022-3069

Haigh, Cathryn L, Lewis, Victoria A, Vella, Laura, Masters, Colin L ORCID: 0000-0003-3072-7940, Hill, Andrew F ORCID: 0000-0001-5581-2354, Lawson, Victoria A ORCID: 0000-0002-7362-7176 and Collins, Steven J (2009) PrP C -related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site. Cell Research, 19. pp. 1062-1078. ISSN 1001-0602

Lawson, Victoria A ORCID: 0000-0002-7362-7176, Vella, Laura J ORCID: 0000-0002-1869-6291, Stewart, James D, Sharples, Robyn A, Klemm, Helen MJ, Machalek, Dorothy, Masters, Colin L ORCID: 0000-0003-3072-7940, Cappai, Roberto ORCID: 0000-0002-9505-8496, Collins, Steven J and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2008) Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture. International Journal of Biochemistry and Cell Biology, 40 (12). pp. 2793-2801. ISSN 1357-2725

Albanese, Valeria ORCID: 0000-0002-9643-7519, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Hill, Andrew F ORCID: 0000-0001-5581-2354, Cappai, Roberto ORCID: 0000-0002-9505-8496, Di Guardo, Giovanni, Staikopoulos, Vasiliki, Thacker, Michelle, Furness, John B ORCID: 0000-0002-0219-3438 and Chiocchetti, Roberto ORCID: 0000-0003-4448-6199 (2008) Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine. Autonomic Neuroscience: Basic and Clinical, 140 (1-2). pp. 17-23. ISSN 1566-0702

Vella, Laura, Sharples, Robyn A, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Masters, Colin L ORCID: 0000-0003-3072-7940, Cappai, Roberto ORCID: 0000-0002-9505-8496 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2007) Packaging of prions into exosomes is associated with a novel pathway of PrP processing. Journal of Pathology, 211 (5). pp. 582-590. ISSN 0022-3417

Brazier, Marcus W, Lewis, Victoria A, Ciccotosto, Giuseppe D, Klug, Genevieve M, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Cappai, Roberto ORCID: 0000-0002-9505-8496, Ironside, James W, Masters, Colin L ORCID: 0000-0003-3072-7940, Hill, Andrew F ORCID: 0000-0001-5581-2354, White, Anthony R ORCID: 0000-0003-1802-9891 and Collins, Steven J (2005) Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease. Brain Research Bulletin, 68 (5). pp. 346-354. ISSN 0361-9230

Collins, Steven J, Lewis, Victoria A, Brazier, Marcus W, Hill, Andrew F ORCID: 0000-0001-5581-2354, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Klug, Genevieve M and Masters, Colin L ORCID: 0000-0003-3072-7940 (2005) Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control. Neurobiology of Disease, 20 (2). pp. 336-346. ISSN 0969-9961

Lawson, Victoria A ORCID: 0000-0002-7362-7176, Collins, Steven J, Masters, Colin L ORCID: 0000-0003-3072-7940 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2005) Prion protein glycosylation. Journal of Neurochemistry, 93 (4). pp. 793-801. ISSN 0022-3042

Book Section

Bellingham, Shayne A ORCID: 0000-0001-5657-7413 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2017) Analysis of miRNA signatures in neurodegenerative prion disease. In: Prions: Methods and Protocols. Lawson, Victoria A, ed. Methods in Molecular Biology, 1658 . Humana Press, Inc, New York, USA, pp. 67-80.

Vella, Laura J ORCID: 0000-0002-1869-6291, Coleman, Bradley M and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2017) Generation of infectious prions and detection with the prion-infected cell assay. In: Prions: Methods and Protocols. Lawson, Victoria A, ed. Methods in Molecular Biology, 1658 . Humana Press, New York, USA, pp. 105-118.