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Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Cheenpracha, Sarot, Zhang, Hao Lan, Mar, Anne M. N, Foss, Adam P, Foo, Sek Hin, Lai, Ngit Shin, Jee, Jap Meng, Seow, Heng-Fong, Ho, Coy Choke and Chang, Leng Chee (2009) Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

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Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3� assay.

Item Type: Article
Uncontrolled Keywords: ResPubID19142. yeast glycogen synthase kinase-3β pathway inhibitors, organic extract of streptomyces sp., microbial fermentation organic extract, imides, glutarimide, propanimide, acetyl acetimide, isoflavonoid glycoside
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Depositing User: VUIR
Date Deposited: 12 Oct 2011 04:11
Last Modified: 12 Feb 2015 06:03
URI: http://vuir.vu.edu.au/id/eprint/4220
DOI: https://doi.org/10.1021/np900163f
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Citations in Scopus: 11 - View on Scopus

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