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Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Cheenpracha, Sarot and Zhang, Hao Lan and Mar, Anne M. N and Foss, Adam P and Foo, Sek Hin and Lai, Ngit Shin and Jee, Jap Meng and Seow, Heng-Fong and Ho, Coy Choke and Chang, Leng Chee (2009) Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

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Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3� assay.

Item Type: Article
Uncontrolled Keywords: ResPubID19142. yeast glycogen synthase kinase-3β pathway inhibitors, organic extract of streptomyces sp., microbial fermentation organic extract, imides, glutarimide, propanimide, acetyl acetimide, isoflavonoid glycoside
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Depositing User: VUIR
Date Deposited: 12 Oct 2011 04:11
Last Modified: 12 Feb 2015 06:03
URI: http://vuir.vu.edu.au/id/eprint/4220
DOI: 10.1021/np900163f
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Citations in Scopus: 4 - View on Scopus

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