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Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats

Ross, Renee M and Wadley, Glenn D and Clark, Michael G and Rattigan, Stephen and McConell, Glenn K (2007) Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats. Diabetes, 56 (12). pp. 2885-2892. ISSN 0012-1797

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Abstract

We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This study examined the effect of local infusion of an NOS inhibitor on skeletal muscle glucose uptake (2-deoxyglucose) and capillary blood flow (contrast-enhanced ultrasound) during in situ contractions in rats.

Item Type: Article
Additional Information:

Online ISSN: 1939-327X

Uncontrolled Keywords: ResPubID22058. local nitric oxide synthase inhibition, skeletal muscle glucose uptake, capillary blood flow, in situ muscle contraction, rats, diabetes
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 03 Apr 2012 01:57
Last Modified: 12 Feb 2015 03:41
URI: http://vuir.vu.edu.au/id/eprint/8017
DOI: 10.2337/db07-0745
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Citations in Scopus: 27 - View on Scopus

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