Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats

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Ross, Renee M, Wadley, Glenn D, Clark, Michael G, Rattigan, Stephen and McConell, Glenn ORCID: 0000-0002-8572-9065 (2007) Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats. Diabetes, 56 (12). pp. 2885-2892. ISSN 0012-1797

Abstract

We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This study examined the effect of local infusion of an NOS inhibitor on skeletal muscle glucose uptake (2-deoxyglucose) and capillary blood flow (contrast-enhanced ultrasound) during in situ contractions in rats.

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Additional Information	Online ISSN: 1939-327X
Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/8017
DOI	10.2337/db07-0745
Official URL	http://dx.doi.org/10.2337/db07-0745
Subjects	Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Historical > FOR Classification > 1106 Human Movement and Sports Science Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords	ResPubID22058. local nitric oxide synthase inhibition, skeletal muscle glucose uptake, capillary blood flow, in situ muscle contraction, rats, diabetes
Citations in Scopus	59 - View on Scopus
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