Yeast-based process for production of I-pac

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Smallridge, Andrew John, Trewhella, Maurice Arthur, Wilkinson, Kylie Anne (2006) Yeast-based process for production of I-pac. United States Patent 7063969.


The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.

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Item type Patent
DOI United States Patent 7063969
Official URL
Subjects Historical > RFCD Classification > 290000 Engineering and Technology
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Keywords yeast-based, i-pac, USP 7063969, supereritical fluid, liquefied gas
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