Neuroinflammatory modulation of extracellular vesicle biogenesis and cargo loading

Spiers, Jereme G ORCID: 0000-0001-5872-8983, Vassileff, Natasha ORCID: 0000-0001-6554-4496 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2022) Neuroinflammatory modulation of extracellular vesicle biogenesis and cargo loading. NeuroMolecular Medicine, 24. pp. 385-391. ISSN 1535-1084


Increasing evidence suggests neuroinflammation is a highly coordinated response involving multiple cell types and utilising several different forms of cellular communication. In addition to the well documented cytokine and chemokine messengers, extracellular vesicles (EVs) have emerged as key regulators of the inflammatory response. EVs act as vectors of intercellular communication, capable of travelling between different cells and tissues to deliver selectively packaged protein, miRNA, and lipids from the parent cell. During neuroinflammation, EVs transmit specific inflammatory mediators, particularly from microglia, to promote inflammatory resolution. This mini-review will highlight the novel neuroinflammatory mechanisms contributing to the biogenesis and selective packaging of EVs.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.1007/s12017-022-08704-3
Official URL
Subjects Current > FOR (2020) Classification > 3101 Biochemistry and cell biology
Current > FOR (2020) Classification > 3204 Immunology
Current > Division/Research > Chancellery
Keywords neuroinflammation, brain health, extracellular vesicles, RNA
Citations in Scopus 5 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login