APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease

Sahakian, Lauren, Robinson, Ainsley, Sahakian, Linda, Stavely, Rhian ORCID: 0000-0002-5099-3704, Kelley, Mark R ORCID: 0000-0001-9472-1826 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2023) APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease. Biomolecules, 13 (11). ISSN 2218-273X


Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. The prevalence of IBD is increasing with approximately 4.9 million cases reported worldwide. Current therapies are limited due to the severity of side effects and long-term toxicity, therefore, the development of novel IBD treatments is necessitated. Recent findings support apurinic/apyrimidinic endonuclease 1/reduction-oxidation factor 1 (APE1/Ref-1) as a target in many pathological conditions, including inflammatory diseases, where APE1/Ref-1 regulation of crucial transcription factors impacts significant pathways. Thus, a potential target for a novel IBD therapy is the redox activity of the multifunctional protein APE1/Ref-1. This review elaborates on the status of conventional IBD treatments, the role of an APE1/Ref-1 in intestinal inflammation, and the potential of a small molecule inhibitor of APE1/Ref-1 redox activity to modulate inflammation, oxidative stress response, and enteric neuronal damage in IBD.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/47592
DOI 10.3390/biom13111569
Official URL https://www.mdpi.com/2218-273X/13/11/1569
Subjects Current > FOR (2020) Classification > 3202 Clinical sciences
Current > FOR (2020) Classification > 3208 Medical physiology
Current > Division/Research > Institute for Health and Sport
Keywords apurinic/apyrimidinic endonuclease 1/reduction-oxidation factor 1 (APE1/Ref-1); redox signaling; inflammatory bowel disease (IBD); inflammation; oxidative stress
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