The ethanol stress response and ethanol tolerance of Saccharomyces cerevisiae

Full text for this resource is not available from the Research Repository.

Stanley, Dragana, Bandara, Ajith, Chambers, Paul J, Fraser, Sarah and Stanley, Grant A (2010) The ethanol stress response and ethanol tolerance of Saccharomyces cerevisiae. Journal of Applied Microbiology, 109 (1). pp. 13-24. ISSN 1364-5072


Saccharomyces cerevisiae is traditionally used for alcoholic beverage and bioethanol production; however, its performance during fermentation is compromised by the impact of ethanol accumulation on cell vitality. This article reviews studies into the molecular basis of the ethanol stress response and ethanol tolerance of S. cerevisiae; such knowledge can facilitate the development of genetic engineering strategies for improving cell performance during ethanol stress. Previous studies have used a variety of strains and conditions, which is problematic, because the impact of ethanol stress on gene expression is influenced by the environment. There is however some commonality in Gene Ontology categories affected by ethanol assault that suggests that the ethanol stress response of S. cerevisiae is compromised by constraints on energy production, leading to increased expression of genes associated with glycolysis and mitochondrial function, and decreased gene expression in energy-demanding growth-related processes. Studies using genome-wide screens suggest that the maintenance of vacuole function is important for ethanol tolerance, possibly because of the roles of this organelle in protein turnover and maintaining ion homoeostasis. Accumulation of Asr1 and Rat8 in the nucleus specifically during ethanol stress suggests S. cerevisiae has a specific response to ethanol stress although this supposition remains controversial.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.1111/j.1365-2672.2009.04657.x
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Historical > FOR Classification > 1003 Industrial Biotechnology
Historical > SEO Classification > 8505 Renewable Energy
Keywords ResPubID21199, biotechnology, fermentation, molecular genetic, stress response, yeasts
Citations in Scopus 298 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login