Retrotransposon expression in ethanol-stressed Saccharomyces cerevisiae

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Stanley, Dragana, Fraser, Sarah, Stanley, Grant A and Chambers, Paul J (2010) Retrotransposon expression in ethanol-stressed Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 87 (4). pp. 1447-1454. ISSN 0175-7598 (print) 1432-0614 (online)


There are five retrotransposon families in Saccharomyces cerevisiae, three (Ty1, Ty2, and Ty3) of which are known to be transcriptionally active. Early investigations reported yeast retrotransposons to be stress-induced; however, microarray-based studies do not report retrotransposition-related Gene Ontology (GO) categories in the ethanol stress response of S. cerevisiae. In this study, microarray technology was used to investigate the ethanol stress response of S. cerevisiae W303-1A, and the highest stress-induced GO categories, based on z-score, were found to be retrotransposition-related, namely, Retrotransposition Nucleocapsid and Transposition, RNA-Mediated. Further investigation, involving reanalysis of previously published results on the stress response of S. cerevisiae, identified the absence of annotation for retrotransposon genes and associated GO categories and their omission during the printing of spotted arrays as two reasons why these categories in previous gene expression studies on the ethanol stress response of yeast were not reported.

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Item type Article
DOI 10.1007/s00253-010-2562
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Historical > FOR Classification > 1003 Industrial Biotechnology
Historical > SEO Classification > 8503 Preparation and Production of Energy Sources
Keywords ResPubID21200, Saccharomyces, ethanol, stress, retrotransposon, gene expression
Citations in Scopus 14 - View on Scopus
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