A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas

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Henson, Jereym, Hannay, Jonathan, McCarthy, Stanley, Royds, Janice, Yeager, Thomas, Robinson, Robert, Wharton, Stephen, Jellinek, David, Arbuckle, Susan, Yoo, Jinyoung, Robinson, Bruce, Learoyd, Diana, Stalley, Paul, Bonar, Fiona, Yu, Dihua, Pollock, Raphael and Reddel, Roger (2005) A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas. Clinical Cancer Research, 11 (1). pp. 217-225. ISSN 1078-0432

Abstract

Telomeres of tumor cells may be maintained by telomerase or by alternative lengthening of telomeres (ALT). The standard ALT assay requires Southern analysis of high molecular weight genomic DNA. We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative.

Additional Information

Online ISSN: 1557-3265

Item type Article
URI https://vuir.vu.edu.au/id/eprint/8496
Official URL http://clincancerres.aacrjournals.org/content/11/1...
Subjects Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Current > FOR Classification > 1112 Oncology and Carcinogenesis
Keywords ResPubID19460, ResPubID22569. ALT-associated PML body, soft tissue sarcoma, astrocytoma, osteosarcoma, bone cancer, glioblastoma multiforme, papillary carcinoma of thyroid, assay, tumours, telomeres, leukemia, DNA
Citations in Scopus 204 - View on Scopus
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