A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas
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Henson, Jeremy, Hannay, Jonathan, McCarthy, Stanley, Royds, Janice, Yeager, Thomas, Robinson, Robert, Wharton, Stephen, Jellinek, David, Arbuckle, Susan, Yoo, Jinyoung, Robinson, Bruce, Learoyd, Diana, Stalley, Paul, Bonar, Fiona, Yu, Dihua, Pollock, Raphael and Reddel, Roger (2005) A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas. Clinical Cancer Research, 11 (1). pp. 217-225. ISSN 1078-0432
Abstract
Telomeres of tumor cells may be maintained by telomerase or by alternative lengthening of telomeres (ALT). The standard ALT assay requires Southern analysis of high molecular weight genomic DNA. We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative.
| Additional Information | Online ISSN: 1557-3265 |
| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/8496 |
| Official URL | http://clincancerres.aacrjournals.org/content/11/1... |
| Subjects | Historical > Faculty/School/Research Centre/Department > School of Engineering and Science Historical > FOR Classification > 1112 Oncology and Carcinogenesis |
| Keywords | ResPubID19460, ResPubID22569. ALT-associated PML body, soft tissue sarcoma, astrocytoma, osteosarcoma, bone cancer, glioblastoma multiforme, papillary carcinoma of thyroid, assay, tumours, telomeres, leukemia, DNA |
| Citations in Scopus | 233 - View on Scopus |
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