Human DNAJ in cancer and stem cells

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Sterrenberg, Jason, Blatch, Gregory ORCID: 0000-0003-0778-8577 and Edkins, Adrienne L (2011) Human DNAJ in cancer and stem cells. Cancer Letters, 312 (2). pp. 129-142. ISSN 0304-3835


Molecular chaperones are the guardians of protein homeostasis in the cell. DNAJ could be regarded as potential "drug targets that chaperone other drug targets". The activities of the DNAJ proteins may mean that these proteins could be more specific and selective drug targets than HSP70 and HSP90.

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Item type Article
DOI 10.1016/j.canlet.2011.08.019
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23324, Molecular chaperones, protein homeostasis, drug targets, HSP70, HSP90, stem cells, cancer, DNAJ, human DNAJ
Citations in Scopus 76 - View on Scopus
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