Human DNAJ in cancer and stem cells
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Sterrenberg, Jason, Blatch, Gregory ORCID: 0000-0003-0778-8577 and Edkins, Adrienne L (2011) Human DNAJ in cancer and stem cells. Cancer Letters, 312 (2). pp. 129-142. ISSN 0304-3835
Abstract
Molecular chaperones are the guardians of protein homeostasis in the cell. DNAJ could be regarded as potential "drug targets that chaperone other drug targets". The activities of the DNAJ proteins may mean that these proteins could be more specific and selective drug targets than HSP70 and HSP90.
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Item type | Article |
URI | https://vuir.vu.edu.au/id/eprint/9022 |
DOI | 10.1016/j.canlet.2011.08.019 |
Official URL | http://dx.doi.org/10.1016/j.canlet.2011.08.019 |
Subjects | Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 0601 Biochemistry and Cell Biology Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences |
Keywords | ResPubID23324, Molecular chaperones, protein homeostasis, drug targets, HSP70, HSP90, stem cells, cancer, DNAJ, human DNAJ |
Citations in Scopus | 76 - View on Scopus |
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