The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete's performance status

[thumbnail of NRF2 and Spanish athletes VUIR.pdf]
Preview
NRF2 and Spanish athletes VUIR.pdf - Accepted Version (485kB) | Preview

Eynon, Nir ORCID: 0000-0003-4046-8276, Ruiz, Jonatan, Bishop, David ORCID: 0000-0002-6956-9188, Santiago, Catalina, Gómez-Gallego, Félix, Lucia, Alejandro and Birk, Ruth (2013) The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete's performance status. Journal of Science and Medicine in Sport, 16 (2). pp. 135-139. ISSN 1440-2440 (print) 1878-1861 (online)

Abstract

Objectives To determine the association between the nuclear respiratory factor 2 (NRF-2) polymorphisms and elite athletic performance. Design We compared the genotype and allele frequencies of the NRF-2 A/C (rs12594956), NRF-2 A/G (rs7181866), and NRF-2 C/T (rs8031031) polymorphisms between world-class endurance athletes (n = 89), elite power-oriented athletes (n = 38), and non-athletic controls (n = 110) of the same Caucasian (Spanish) origin. Methods Genomic DNA was extracted from peripheral EDTA-treated, anti-coagulated blood using a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). Results The frequency of the AA genotype of the NRF-2 A/C (rs12594956) polymorphism was significantly higher in endurance athletes compared with power athletes (P < 0.01) and controls (P < 0.01) (48% vs. 13% and 21%, respectively). The likelihood of having the AA (rs12594956) genotype was higher in elite endurance athletes compared with controls [odds ratio (OR): 3.536, 95% confidence interval (CI): 1.903–6.571] and elite power athletes (OR: 6.170, 95%CI: 2.206–17.253). Conclusions Our results suggest that the NRF-2 A/C polymorphism might belong to a growing group of polymorphisms associated with endurance performance at the elite level. However, it is important to replicate these findings in other groups of elite athletes using larger sample sizes.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/23463
DOI 10.1016/j.jsams.2012.05.004
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Current > Division/Research > College of Sports and Exercise Science
Keywords ResPubID25468, ResPubID26693, genetics, transcription factors, exercise, polymorphism
Citations in Scopus 19 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login