Zhang, Ya-xu, Dong, Wei, Liu, Hui, Cicuttini, Flavia, de Courten, Maximilian and Yang, Jian-bai (2010) Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin–Beck disease. Clinical Rheumatology, 29 (4). pp. 357-362. ISSN 0770-3198 (print) 1434-9949 (online)

Abstract

The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin–Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo twice daily for 8 months. Posteroanterior radiographs of bilateral knee in full extension were taken at enrollment and after 8 months. Mean joint-space width of the assigned six points on the tibiofemoral joint compartment was measured by a graduated magnifying lens. The mean joint space decreased significantly in the placebo group (4.3 ± 1.09 versus 4.1 ± 1.07 mm, P < 0.0001) after 8 months and was unchanged in the experimental group (P = 0.51). There was no statistical significance in the mean joint space between two groups at baseline and follow-up (P = 0.65 and P = 0.84, respectively). But the overall mean change in joint space was significant between the two groups (P < 0.0001). Knee joint space of the experimental group narrowed slowly compared to the control group. Therefore, chondroitin sulfate and glucosamine might play a protective role in preserving articular cartilage and provide evidence for therapeutic drugs in adult patients with KBD.

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