Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity

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Kong, Lih L, Omar, A. R, Hair-Bejo, M, Aini, I and Seow, Heng-Fong (2004) Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity. Archives of Virology, 149 (2). pp. 425-434. ISSN 0304-8608

Abstract

The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.

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Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/2616
DOI	10.1007/s00705-003-0206-6
Official URL	http://link.springer.com/article/10.1007%2Fs00705-...
Subjects	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1107 Immunology
Keywords	ResPubID19029, Infectious bursal disease virus, IBDV, ancestral virus
Citations in Scopus	28 - View on Scopus
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