Focus on extracellular vesicles: exosomes and their role in protein trafficking and biomarker potential in Alzheimer’s and Parkinson’s disease

Vella, Laura, Hill, Andrew F ORCID: 0000-0001-5581-2354 and Cheng, Lesley (2016) Focus on extracellular vesicles: exosomes and their role in protein trafficking and biomarker potential in Alzheimer’s and Parkinson’s disease. International Journal of Molecular Sciences, 17 (2). ISSN 1661-6596

Abstract

Growing evidence indicates that small extracellular vesicles, called exosomes, are prominent mediators of neurodegenerative diseases such as prion, Alzheimer’s and Parkinson’s disease. Exosomes contain neurodegenerative disease associated proteins such as the prion protein, β-amyloid and α-synuclein. Only demonstrated so far in vivo with prion disease, exosomes are hypothesised to also facilitate the spread of β-amyloid and α-synuclein from their cells of origin to the extracellular environment. In the current review, we will discuss the role of exosomes in Alzheimer’s and Parkinson’s disease including their possible contribution to disease propagation and pathology and highlight their utility as a diagnostic in neurodegenerative disease.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/45590
DOI 10.3390/ijms17020173
Official URL https://www.mdpi.com/1422-0067/17/2/173
Subjects Current > FOR (2020) Classification > 3207 Medical microbiology
Current > Division/Research > Chancellery
Keywords exosomes, prion disease, Alzheimer's disease, Parkinson's disease, neurodegenerative disorder
Citations in Scopus 151 - View on Scopus
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