The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes

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Guo, Belinda B, Bellingham, Shayne A ORCID: 0000-0001-5657-7413 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2015) The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. Journal of Biological Chemistry, 290 (6). pp. 3455-3467. ISSN 0021-9258

Abstract

Background: Exosomes are a novel mechanism of intercellular transmission of infectious prions. Results: Chemical and RNAi inhibition of the neutral sphingomyelinase (nSMase) pathway impairs exosome formation and prion packaging. Conclusion: The nSMase pathway regulates exosome formation and packaging of infectious prions. Significance: This reveals a novel role for the nSMase pathway in exosomal prion packaging and identifies a direct pathway, which mediates prion transmission.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/45826
DOI 10.1074/jbc.M114.605253
Official URL https://www.sciencedirect.com/science/article/pii/...
Subjects Current > FOR (2020) Classification > 3207 Medical microbiology
Current > Division/Research > Chancellery
Keywords prion disease, neurodegenerative disease, misfolding, prion protein
Citations in Scopus 158 - View on Scopus
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