Effect of Exercise Training on Insulin Sensitivity, Mitochondria and Computed Tomography Muscle Attenuation in Overweight Women With and Without Polycystic Ovary Syndrome

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Hutchison, Samantha K, Teede, Helena J, Rachon, Dominik, Harrison, Cheryce L, Strauss, Boyd J and Stepto, Nigel ORCID: 0000-0002-0875-6836 (2012) Effect of Exercise Training on Insulin Sensitivity, Mitochondria and Computed Tomography Muscle Attenuation in Overweight Women With and Without Polycystic Ovary Syndrome. Diabetologia, 55 (5). pp. 1424-1434. ISSN 0012-186X (print), 1432-0428 (online)

Abstract

Polycystic ovary syndrome (PCOS) is an insulin resistant (IR) state. Increased skeletal muscle lipid content and impaired mitochondrial biogenesis have been implicated in the pathogenesis of IR. We investigated whether differences in these variables explain the IR of women affected by PCOS and whether improvements in IR with exercise are reflected by changes in these variables.

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Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/9071
DOI	10.1007/s00125-011-2442-8
Official URL	http://dx.doi.org/10.1007/s00125-011-2442-8
Funders	http://purl.org/au-research/grants/nhmrc/606553
Subjects	Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL) Historical > FOR Classification > 1106 Human Movement and Sports Science Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords	ResPubID23449, ResPubID25389, polycystic ovary syndrome, overweight women, body mass index, BMI, obesity, type 2 diabetes, muscles
Citations in Scopus	39 - View on Scopus
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