Article

Timpani, Cara ORCID: 0000-0003-4567-4319, Rasmussen, Lorna and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2023) Adenylosuccinic Acid Is a Non-Toxic Small Molecule In Vitro and In Vivo. Pharmaceuticals, 16 (10). ISSN 1424-8247

Cree, Tabitha, Gomez, Tania Ruz, Timpani, Cara ORCID: 0000-0003-4567-4319, Rybalka, Emma ORCID: 0000-0002-4854-0036, Price, John ORCID: 0000-0002-8244-1023 and Goodman, Craig ORCID: 0000-0002-5874-7743 (2023) FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation. The FEBS Journal, 290 (19). pp. 4660-4678. ISSN 1742-464X

Rybalka, Emma ORCID: 0000-0002-4854-0036, Kourakis, Stephanie ORCID: 0000-0001-5683-9989, Bonsett, Charles A, Moghadaszadeh, Behzad ORCID: 0000-0001-9787-0106, Beggs, Alan H ORCID: 0000-0001-8818-0568 and Timpani, Cara ORCID: 0000-0003-4567-4319 (2023) Adenylosuccinic acid: an orphan drug with untapped potential. Pharmaceuticals, 16 (6). ISSN 1424-8247

Campelj, Dean G, Timpani, Cara ORCID: 0000-0003-4567-4319 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2022) Cachectic muscle wasting in acute myeloid leukaemia: a sleeping giant with dire clinical consequences. Journal of Cachexia, Sarcopenia and Muscle, 13 (1). pp. 42-54. ISSN 2190-5991

Kourakis, S, Timpani, Cara ORCID: 0000-0003-4567-4319, Campelj, Dean G, Hafner, P, Gueven, Nuri, Fischer, Dirk and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2021) Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better? Orphanet Journal of Rare Diseases, 16 (1). ISSN 1750-1172 (In Press)

Timpani, Cara ORCID: 0000-0003-4567-4319 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2021) Calming the (Cytokine) storm: Dimethyl fumarate as a therapeutic candidate for covid-19. Pharmaceuticals, 14 (1). pp. 1-15. ISSN 1424-8247 (In Press)

Campelj, Dean G, Timpani, Cara ORCID: 0000-0003-4567-4319, Cree, Tabitha, Petersen, Aaron ORCID: 0000-0003-1508-748X, Hayes, Alan ORCID: 0000-0003-1398-3694, Goodman, Craig ORCID: 0000-0002-5874-7743 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2021) Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle For Myopathy But Does Not Cause Cachexia. Pharmaceuticals, 14 (5). ISSN 1424-8247

Rybalka, Emma ORCID: 0000-0002-4854-0036 and Timpani, Cara ORCID: 0000-0003-4567-4319 (2021) Micro (mRNA) molecules could pack a big punch in the fight against neuromuscular disease. Journal of Physiology, 599 (1). pp. 5-6. ISSN 0022-3751

Kourakis, Stephanie ORCID: 0000-0001-5683-9989, Timpani, Cara ORCID: 0000-0003-4567-4319, de Haan, Judy B, Gueven, Nuri, Fischer, Dirk and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2021) Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy. Redox Biology, 38. ISSN 2213-2317

Rybalka, Emma ORCID: 0000-0002-4854-0036, Timpani, Cara ORCID: 0000-0003-4567-4319, Debruin, Danielle A, Bagaric, RM ORCID: 0000-0002-2286-2870, Campelj, Dean G and Hayes, Alan ORCID: 0000-0003-1398-3694 (2020) The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle. Cells, 9 (12). ISSN 2073-4409

Campelj, Dean G, Timpani, Cara ORCID: 0000-0003-4567-4319, Petersen, Aaron ORCID: 0000-0003-1508-748X, Hayes, Alan ORCID: 0000-0003-1398-3694, Goodman, Craig ORCID: 0000-0002-5874-7743 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2020) The paradoxical effect of parp inhibitor bgp-15 on irinotecan-induced cachexia and skeletal muscle dysfunction. Cancers, 12 (12). pp. 1-28. ISSN 2072-6694

Timpani, Cara ORCID: 0000-0003-4567-4319, Mamchaoui, K, Butler-Browne, Gillian and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2020) Nitric oxide (NO) and duchenne muscular dystrophy: NO way to go? Antioxidants, 9 (12). pp. 1-8. ISSN 2076-3921

Kourakis, Stephanie ORCID: 0000-0001-5683-9989, Timpani, Cara ORCID: 0000-0003-4567-4319, de Haan, Judy B, Gueven, Nuri, Fischer, Dirk and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2020) Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? Pharmaceuticals, 13 (10). ISSN 1424-8247

Campelj, Dean G, Debruin, Danielle A, Timpani, Cara ORCID: 0000-0003-4567-4319, Hayes, Alan ORCID: 0000-0003-1398-3694, Goodman, Craig ORCID: 0000-0002-5874-7743 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2020) Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice. Scientific Reports, 10. ISSN 2045-2322

Debruin, Danielle A, Timpani, Cara ORCID: 0000-0003-4567-4319, Lalunio, H, Rybalka, Emma ORCID: 0000-0002-4854-0036, Goodman, Craig ORCID: 0000-0002-5874-7743 and Hayes, Alan ORCID: 0000-0003-1398-3694 (2020) Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice. Journal of Bone and Mineral Research, 35 (6). ISSN 0884-0431

Timpani, Cara ORCID: 0000-0003-4567-4319, Goodman, Craig ORCID: 0000-0002-5874-7743, Stathis, Christos ORCID: 0000-0003-0064-9523, White, Jason D, Mamchaoui, Kamel, Butler-Browne, Gillian, Gueven, Nuri, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2020) Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy. Scientific Reports, 10. ISSN 2045-2322

Debruin, Danielle A, Andreacchio, Nicola, Hanson, Erik ORCID: 0000-0002-7744-5652, Timpani, Cara ORCID: 0000-0003-4567-4319, Rybalka, Emma ORCID: 0000-0002-4854-0036 and Hayes, Alan ORCID: 0000-0003-1398-3694 (2019) The Effect of Vitamin D Supplementation on Skeletal Muscle in the mdx Mouse Model of Duchenne Muscular Dystrophy. Sports, 7 (5). ISSN 2075-4663

McQuade, Rachel, Stojanovska, Vanesa, Stavely, Rhian, Timpani, Cara ORCID: 0000-0003-4567-4319, Petersen, Aaron ORCID: 0000-0003-1508-748X, Abalo, Raquel, Bornstein, Joel C ORCID: 0000-0002-7518-7717, Rybalka, Emma ORCID: 0000-0002-4854-0036 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2018) Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15. British Journal of Pharmacology, 175 (4). 656 - 677. ISSN 0007-1188

Rybalka, Emma ORCID: 0000-0002-4854-0036, Timpani, Cara ORCID: 0000-0003-4567-4319, Cheregi, Beatrice, Sorensen, James, Nurgali, Kulmira ORCID: 0000-0002-2597-6929 and Hayes, Alan ORCID: 0000-0003-1398-3694 (2017) Chemotherapeutic agents induce mitochondrial superoxide production and toxicity but do not alter respiration in skeletal muscle in vitro. Mitochondrion. 1 - 1. ISSN 1567-7249

Timpani, Cara ORCID: 0000-0003-4567-4319, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2017) Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy. Orphanet Journal of Rare Diseases, 12 (1). 100 - 100. ISSN 1750-1172

Sorensen, James, Petersen, Aaron ORCID: 0000-0003-1508-748X, Timpani, Cara ORCID: 0000-0003-4567-4319, Campelj, Dean G, Cook, Jordan, Trewin, Adam, Stojanovska, Vanesa, Stewart, Mathew, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2017) BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice. Frontiers in Pharmacology, 8. ISSN 1663-9812

Timpani, Cara, Trewin, Adam, Stojanovska, Vanesa, Robinson, Ainsley, Goodman, Craig ORCID: 0000-0002-5874-7743, Nurgali, Kulmira ORCID: 0000-0002-2597-6929, Betik, Andrew C, Stepto, Nigel ORCID: 0000-0002-0875-6836, Hayes, Alan ORCID: 0000-0003-1398-3694, McConell, Glenn ORCID: 0000-0002-8572-9065 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2017) Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle. Neurotherapeutics, 14 (2). 429 - 446. ISSN 1933-7213

Sorensen, James, Cheregi, Beatrice, Timpani, Cara, Nurgali, Kulmira ORCID: 0000-0002-2597-6929, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2016) Mitochondria: inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting? Cancer Chemotherapy and Pharmacology. ISSN 0344-5704

Rybalka, Emma ORCID: 0000-0002-4854-0036, Timpani, Cara, Stathis, Christos, Hayes, Alan ORCID: 0000-0003-1398-3694 and Cooke, Matthew (2015) Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy. Nutrients, 7 (12). 9734 - 9767. ISSN 2072-6643

Timpani, Cara, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2015) Revisiting the dystrophin-ATP connection: How half a century of research still implicates mitochondrial dysfunction in Duchenne Muscular Dystrophy aetiology. Medical Hypotheses. ISSN 0306-9877 (In Press)

Rybalka, Emma ORCID: 0000-0002-4854-0036, Timpani, Cara, Cooke, Matthew, Williams, AD and Hayes, Alan ORCID: 0000-0003-1398-3694 (2014) Defects in Mitochondrial ATP Synthesis in Dystrophin-Deficient Mdx Skeletal Muscles May Be Caused by Complex I Insufficiency. PLoS ONE, 9 (12). ISSN 1932-6203

Conference or Workshop Item

Stojanovska, Vanesa, Stewart, M, McQuade, Rachel, Timpani, Cara ORCID: 0000-0003-4567-4319, Sorensen, James, Orbell, John ORCID: 0000-0003-3485-5309, Rybalka, Emma ORCID: 0000-0002-4854-0036 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2016) Platinum accumulation and changes in mitochondrial function of the longitudinal muscle and myenteric plexus following oxaliplatin administration. In: 2nd Federation of Neurogastroenterology and Motility Meeting, 25 August 2016 - 28 August 2016, San Francisco, California.

Blazev, Ronnie, Timpani, Cara, McConell, Glenn ORCID: 0000-0002-8572-9065, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2015) The effect of nitrate supplementation on sarcoplasmic reticulum Ca2+ handling in dystrophic skeletal muscle fibres. In: AuPS 2015, 29 November 2015-02 December 2015, Hobart, Tasmania, Australia.

Hayes, Alan ORCID: 0000-0003-1398-3694, Andreacchio, Nicola, Timpani, Cara, Hanson, Erik and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2015) Effects of vitamin D supplementation on dystrophic (mdx) muscles during damage and repair. In: Australian Physiological Society Meeting, 29 November 2015-02 December 2015, Hobart, Tasmania.

Sorensen, James, Timpani, Cara ORCID: 0000-0003-4567-4319, Campelj, Dean G, Petersen, Aaron ORCID: 0000-0003-1508-748X, Hayes, Alan ORCID: 0000-0003-1398-3694 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2015) Idebenone protects against chemotherapy-induced skeletal muscle wasting and mitochondrial dysfunction in mice. In: AuPS 2015, 29 Nov 2015 - 2 Dec 2015, Hobart, Australia.

Monograph

Rybalka, Emma ORCID: 0000-0002-4854-0036 and Timpani, Cara (2015) Duchenne Muscular Dystrophy as a mitochondrial myopathy: Why therapeutically targeting the mitochondria is a plausible treatment avenue. Project Report. Victoria University, Melbourne, Australia.

Thesis

Timpani, Cara (2017) Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy. PhD thesis, Victoria University.